Fat Emperor in LC USA Keto Getaway Florida - Insulin Vs Cholesterol - and CAC !

Had a great time in South Beach Miami and West Palm Beach also - got a pile of content with the fantastic camera crew Simon and Giorgos from www.dietdoctor.com - watch out for our many Miami interviews and vox pops on the world's biggest LCHF website ! 

Also gave uncompromising talk at Low Carb USA's Keto Getaway in West Palm Beach - note that this is just captured using my little video camera, not the 4K monsters from the DietDoctor crew! Here I introduce the importance of the Adipose...  Nice little Q&A afterwards also. I've a rather hardcore version of this talk which I gave at Physician's for Ancestral Health event in Miami Beach a couple days earlier. It'll be out soon but be warned...it's a little hardcore indeed ;-) And mustn't forget Ireland's foremost Histopathologist Gearoid O'Laoí - for coining the term "Sick Fat" !

Myself and Dr. Jeffry Gerber (http://denversdietdoctor.com/) will have a book coming out late in 2017 with this and much more analysis of how to live long - and with healthy vitality to the end!

Slidepack used is available here:  https://ivor-cummins.squarespace.com/s/20170110-MIAMI-INSULIN-LOW-CARB-TALK-Final.pdf

See the superb "Widowmaker" movie here:  https://vimeo.com/ondemand/thewidowmakermovie2015 

Or here:  https://itunes.apple.com/ie/movie/the-widowmaker/id960575237 https://www.amazon.com/Widowmaker-Gillian-Anderson/dp/B00U2BZPD4

Don't forget to go to www.IHDA.ie for heart disease prevention, and subscribe to www.thefatemperor.com/subscribe to support future FREE content !

A non-complete selection of papers referenced in preparing this content with Gabor Erdosi's help (he dug out a lot of 'em!):

Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward Atherosclerosis 247 (2016) 225e282

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009Diabetologia (2010) 53:1270–1287

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production Titchenell et al., 2016, Cell Metabolism 23, 1–13

SULF2 Strongly Predisposes to Fasting and Postprandial Triglycerides in Patients with Obesity and Type 2 Diabetes Mellitus Obesity (Silver Spring). 2014 May ; 22(5): 1309–1316.


De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose Biological Reviews 91 (2016) 452–468

PKC-θ knockout mice are protected from fat-induced insulin resistance     J. Clin. Invest. 114:823–827 (2004).

Protein kinase Cdeficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodelingJournal of Lipid Research Volume 53, 2012

Inhibition of PKC¯ Improves Glucocorticoid-Induced Insulin Resistance in Rat AdipocytesLife, 54: 365–370, 2002

Obesity and insulin resistanceThe Journal of Clinical Investigation | August 2000 | Volume 106 | Number 4

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes molecular cell biology volume 9May 2008

Increased glucose uptake promotes oxidative stress and PKC- activation in adipocytes of obese, insulin-resistant mice Am J Physiol Endocrinol Metab 285: E295–E302, 2003

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver NATURE |VOL 409 | 8 FEBRUARY 2001 |www.nature.com

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance Diabetes Publish Ahead of Print, published online March 25, 2016

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism 9A P R I L2 0 1 2   VO L 4 8 4   N AT U R E

Normal muscle glucose uptake in mice deficient in muscle GLUT4 Journal of Endocrinology (2012) 214, 313–327

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism NATURE COMMUNICATIONS | 7:11365 | DOI: 10.1038/ncomms11365

De novo lipogenesis in human fat and liver is linked to ChREBP-b and metabolic health NATURE COMMUNICATIONS | 4:1528 | DOI: 10.1038/ncomms2537 |www.nature.com/naturecommunications

Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity A Driver for Ectopic Fat Deposition? DIABETES, VOL. 60, JANUARY 2011

Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men www.ScienceTranslationalMedicine.org 9 September 2015 Vol 7 Issue 304 304re7

GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects Diabetes 2016;65:1808–1815

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism Cell. 2008 September 19; 134(6): 933–944.

Targeted Overexpression of Inducible 6-Phosphofructo-2-kinase in Adipose Tissue Increases Fat Deposition but Protects against Diet-induced Insulin Resistance and Inflammatory Responses*  THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 25, pp. 21492–21500, June 15, 2012

Insulin Resistance - A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease DIABETES CARE, VOL. 14, NO. 3, MARCH 1991

Excess exposure to insulin may be the primary cause of insulin resistance Am J Physiol Endocrinol Metab 298: E372, 2010

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet. Journal of Endocrinology (2014) 221, 469–480

Skeletal Muscle Insulin Resistance in Normoglycemic Subjects With a Strong Family History of Type 2 Diabetes Is Associated With Decreased Insulin-Stimulated Insulin Receptor Substrate-1 Tyrosine Phosphorylation DIABETES, VOL. 50, NOVEMBER 2001

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes Nat Rev Mol Cell Biol. 2008 May ; 9(5): 367–377.

Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cellsHammarstedt et al. Diabetology & Metabolic Syndrome 2012, 4:42

Impaired (‘diabetic’) insulin signaling and action occur in fat cells long before glucose intolerance—is insulin resistance initiated in the adipose tissue? International Journal of Obesity (2002) 26, 897–904

Arachidonic acid has a dominant effect to regulate lipogenic genes in 3T3-L1 adipocytes compared to omega-3 fatty acidsFood & Nutrition Research 2015, 59: 25866

Omega-6 polyunsaturated fatty acids and the early origins of obesity Curr Opin Endocrinol Diabetes Obes 2013, 20:56–61

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux J Clin Invest. 2016;126(1):12–22.

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 DiabetesPerry et al., 2015, Cell 160, 1–14

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acidsPNAS | January 27, 2015 | vol. 112 | no. 4 | 1143–1148

Plasma non-esterified fatty acids: why are we not measuring them routinely? Ann Clin Biochem 2005; 42: 413–414

Impaired Free Fatty Acid Suppression During Hyperinsulinemia Is a Characteristic Finding in Familial Combined Hyperlipidemia, but Insulin Resistance Is Observed Only in Hypertriglyceridemic Patients Arterioscler Thromb Vasc Biol. 2000;20:164-170.)

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production Titchenell et al., 2016, Cell Metabolism 23, 1–13

Glucose and Free Fatty Acid Metabolism in Non-insulin-dependent Diabetes Mellitus   J. Clin. Invest. Volume 84, July 1989, 205-213

The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjectsJ. Clin. Invest. 103:365–372 (1999).

Effects of Free Fatty Acid Elevation on Postabsorptive Endogenous Glucose Production and Gluconeogenesis in Humans DIABETES, VOL. 49, MAY 2000

Effects of Free Fatty Acids Per Se on Glucose Production, Gluconeogenesis, and Glycogenolysis  DIABETES, VOL. 52, FEBRUARY 2003

Free Fatty Acid as a link in the Regulation of Hepatic Glucose Output by Peripheral InsulinDIABETES, VOL. 44, SEPTEMBER 1995

Stearoyl-CoA desaturase and insulin signaling — What is the molecular switch? Biochimica et Biophysica Acta 1797 (2010) 1189–1194

Hepatic lipogenesis independent of insulin in type 2 diabetes mellitus—a paradox clarifiedProc. Natl Acad. Sci. USA doi:10.1073/pnas.1423952112

Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise TrainingCompr Physiol. 2013 January ; 3(1): 1–58.

Lipid-Induced Insulin Resistance in Skeletal Muscle: The Chase for the Culprit Goes from Total Intramuscular Fat to Lipid Intermediates, and Finally to Species of Lipid IntermediatesNutrients 2016, 8, 466

Fatty Acids, Obesity, and Insulin Resistance: Time for a ReevaluationDIABETES, VOL. 60, OCTOBER 2011

Impaired (‘diabetic’) insulin signaling and action occur in fat cells long before glucose intolerance—is insulin resistance initiated in the adipose tissue? International Journal of Obesity (2002) 26, 897 – 904.



Ireland's Top Dietician: Sugar is not a big deal, and #LCHF is Stupid Fad ;-)

The title says it all - one of Ireland's top consultant dieticians (with multiple nutrition degrees) let's us know what healthy eating is all about. It's only about the calories - that's what counts. Breakfast cereals are full of great nutrition, with relatively few calories. Carbs are irrelevant physiologically - it's the calories stupid. We're just eating too much is all. Most importantly, we need to properly follow the current guidelines and then "no-one would be overweight or obese".

Unmissable and classic piece of risible radio - enjoy!

p.s. Here's the "scientific" study referenced - even worse than the usual associational claptrap http://gibneyonfood.blogspot.nl/2017/01/think-sweet-stay-slim.html Excerpt: "The NutriSanté study is an internet-based study, initiated in 2009.....Each month, volunteers are invited to complete questionnaires related among other things to food behaviour.....". Yep - an internet-survey based associational twaddle asking about food preferences. Eight out of ten scientist cats in our survey said this paper is junk (the other two are on food company payroll).

TED Talk from Dr. Rangan Chatterjee: putting Insulin Resistance centre-stage!

Too busy for posts lately, but can't miss this one. I first met Rangan in London last November at Darryl Edward's "Health Unplugged" conference. He appeared out of nowhere, treating me to an enormous handshake - and also his trademark intense authenticity. This guy means everything he says - and he's bang on the money to boot.

Hope you enjoy this excellent TED talk (his first) as much as I did. It's so fulfilling to see the focus moving to genuine root cause resolution. Every doctor needs to view the world as Rangan does; attend to the causes - not the symptoms...! :-)

Please share like hell...and subscribe to www.thefatemperor.com/subscribe too while yer at it... :-)

Note: just as a primer on the importance of Insulin Resistance status, see here what Gerald Reaven saw when he followed ~250 random 60-year-olds for around six years. He split them into low, medium and high Insulin Resistance tertiles up front - guess who got all the bad outcomes? Right:

"The Complete Guide to Fasting" (Dr. Jason Fung / Jimmy Moore) - Book Review !

Let me have men about me that are fat,

Sleek-headed men and such as sleep a-nights.

Yond Cassius has a lean and hungry look.

He thinks too much. Such men are dangerous” (Julius Caesar 1.2.8)

I have long practised the art of fasting; for the weight control benefits sure – but also for the health and mental wellbeing that it affords. On the latter it is much more than mere wellbeing by the way. Fasting enables an extraordinary boost in mental acuity. With no doubt whatsoever, I am at my sharpest and most capable when fasted for about 20 hours or more. Thus I prepare for stressful or challenging situations – by not eating for a long period in advance.

Reading “The Complete Guide to Fasting” was a hugely enjoyable experience. While doing so the above quote from Julius Caesar sprang into my mind. Caesar sees the danger in Cassius, his intellect honed from lack of overfeeding. Deep down might we all like to be Cassius?  Perhaps not the dangerous piece. But certainly the lean and sharp-minded aspects. How do we achieve this state of body and mind? How do we reverse metabolic disease and poor health status? Is it just by old-fashioned calorie-counting, and perhaps getting your macros right (i.e. healthy LCHF)?

I don’t think so. I rather agree with Jason and Jimmy’s premise in this book. The ‘diet-and-exercise’ and ‘eat at regular intervals’ advice has been trotted out for the past 50 years. But the dietary elements (and eating patterns encouraged) flew in the face of evolutionary evidence. With high carbohydrate and regular ‘grainy snacks’, we have spawned an enormous diabetes epidemic (over half of adult Americans are now pre-diabetic or diabetic). The modern population is indeed in a difficult place. It will require a return to evolutionary principles to set us free.

The book lays out all aspects of Fasting’s ancient practice, explaining the science behind the many benefits. It starts off by contrasting the terms ‘starvation’ and ‘fasting’. The former is forced on a person, the latter is by choice. There is an enormous difference. You will however hear people deceitfully use the term ‘starvation’ in order to attack the practice of fasting. Ignore these idiots. We see that fasting essentially switches the fuel source from what you put in your mouth, to what you carry around your middle. The biochemistry is beautiful – elegantly switching to ancient processes of bodyfat oxidation, both healthy and entirely appropriate. Many other biochemical benefits are triggered by fasting, including the positive boost in Human Growth Hormone (HGH). This has a key role in preserving muscle and leads to many other parallel benefits for longevity.

Chapter two covers the fascinating historical background of the practice itself. All religions have fasted in various ways. Nearly all cultures have valued its benefits. Over the past few decades, however, our western industrialised society has consistently undermined the ancient practice. Why is this? Well, the food, advertising and other industries have a huge stake in the consumer society. They care little of the threat from ‘reduce your calories’ (they are well aware that this jaded junk-advice doesn’t work for long). The concept of deploying ancestral wisdom is another matter entirely. To have fasting become a valued and common pursuit…is quite a frightening spectre to the money men. And so it must be rubbished and dismissed as ‘unhealthy and dangerous’.  In chapter three we get an entertaining run-through of all the myths that have been crafted to protect the profits. We also get a super summary of the truth that belies every single myth. I was reminded of the cholesterol myths we have suffered for so long – the same ruinous rulebook has been applied to fasting. We have been made fools of for decades – but now it is time to wake the hell up.

Chapters four brings us on a journey that is as convincing as it is captivating. Have you any idea of the sheer diversity and magnitude of fasting’s advantages? You certainly will after these chapters – and want to start getting hold of them for yourself! What emerges is a picture in stark contrast to what we’ve been told for generations. With fasting the bad gets minimised, the good gets better – across a dizzying array of advantages you can create for yourself. All are lined up like in an ammo belt: Simple, Free, Convenient, Pleasure-Enabling, Powerful, Flexible, …and it works with ANY chosen diet. Explained too is fasting as one of the most powerful tools in the box; it can deal with challenges that are resistant to LCHF and many other approaches – challenges which quail in the face of fasting. It is that powerful. You are free to wield this tool for yourself…after internalising the content of this book.

The next chapters bring us through the profound problems of weight-loss and type 2 diabetes. You guessed it – the power of fasting comes into its own here. Peppered throughout the text are real-life affidavits from Jason’s practice which illustrate what can be achieved. As always, the supporting science is referred to and explained – without slowing the pace with heavy or boring detail. We get to see the enormous benefits which fasting can deliver against Alzheimer’s, Heart Disease and many other modern inflammatory conditions. As mentioned I have been fasting for many years now, and have strong thoughts on the ways in which hunger can be mastered with the right approaches; in chapter nine we get a superb summary of how to do this. Importantly, there are explanations of the mechanisms behind detrimental feelings of hunger – and how they can be sidestepped gracefully. I love it.

Time is pressing so here I will wrap up. There is a comprehensive Section 2 which gives all the protocols for successfully implementing a range of fasting regimes. All common variants are covered carefully, to enable all types of fasting. With this section you can become an expert in the art. You’ll never look back. The final section 3 has a range of delicious recipes, for the times when you are not indulging in the mind and body-enhancing attributes of the ancient remedy.

Get this book, and you too can be a kind of Cassius; lean, focussed and sharp-witted. But without the dangerous streak maybe…unless you like that sort of thing !

The book:  https://www.amazon.co.uk/Complete-Guide-Fasting-Jason-Fung/dp/1628600012/ref=sr_1_1/256-8433904-0165728?ie=UTF8&qid=1478264147&sr=8-1&keywords=complete+guide+to+fasting

..and see my video chat with Jason on the fasting topic here:

Part 1:  https://www.youtube.com/watch?v=kU5bc3Fja34

Part 2:  https://www.youtube.com/watch?v=t6QyQ2svKns

…and don’t forget to subscribe for free at www.thefatemperor.com/subscribe ;-)

Note: the Cassius analogy of course applies equally to male or female participants – no sexism on this site !

Free Preview of Fat Emperor San Diego riff - Heart Disease primary root causes !

FREE PREVIEW of my July #LowCarbUSA talk in San Diego; join up with Diet Doctor and see masses of content which will (enjoyably) extend your productive lifespan...! :-)  - the sneak preview below - subscribe for free at www.thefatemperor.com/subscribe - for always-free content...

Fat Emperor turns up on Christopher Kelly's KETO SUMMIT - enjoy !

Had a great chat with Christopher on his excellent Keto Summit - free registration to watch within next 36 hours at http://ketosummit.com/ ! Click on image below to watch... :-)

Link here also http://ketosummit.com/launch-day-6

Below links to the full summit with many superb speakers and great science - also some other great products that Christopher has produced for minimal price...

Keto Summit Opt-in / Registration:   https://mz164.isrefer.com/go/ketosummit/TheFatEmperor/

Keto Summit - Cancer (Seyfried Video):   https://mz164.isrefer.com/go/cancer-seyfried/TheFatEmperor/

30-Minute Paleo Dessert Recipes: https://mz164.isrefer.com/go/paleo-dessert-recipe/TheFatEmperor/

Essential Keto Cookbook: https://mz164.isrefer.com/go/ekc/TheFatEmperor/

Essential Paleo Cookbook:   https://mz164.isrefer.com/go/epc/TheFatEmperor/


Short Informational Video on CAC / Calcium Scanning - dodge that Heart Attack!

A short professional summary of Calcium Scanning technology, and what it can offer to the millions with hidden heart disease. Remember that since 2013, CAC is in the US and European guidelines - recommended for 'middle-risk' people. These are the largest group - where MOST heart attacks occur! So why aren't we using this amazing test, that takes a few minutes - and actually SEES the atherosclerotic disease itself? Well sadly, most doctors (and even cardiologists) have no idea of its power - for business-centric and other reasons. But all potential US Presidents and astronauts MUST have a CAC scan before taking office - because it is the ultimate test for heart disease presence. So don't sell yourself short - your life is as important as those guys, right? At the end of this post is a short primer on the important root causes you can address to resolve atherosclerosis (if your score is indeed high)

For more details see www.IHDA.ie

...and see the riveting Widowmaker Movie at Netflix USA: https://flixsearch.io/movie/the-widowmaker-2015

...or on iTunes: https://itunes.apple.com/ie/movie/the-widowmaker/id960575237

And after seeing the movie, would you still want to depend on 'risk factors' to guess if you have serious heart disease and all-cause mortality risk? Hardly - look at those so-called 'risk factors' versus CAC in predicting death below:

 CAC   sees   the disease -  and how bad that disease is :

CAC sees the disease - and how bad that disease is:

You want another view of how powerfully your CAC score predicts death, if you don't take action? Ok then, have a look:

 CAC: Nothing comes close in telling you how it is inside

CAC: Nothing comes close in telling you how it is inside

You want to roll the dice with that noisy BS 'Framingham Risk' confection? I wouldn't if I were you - I'd get a CAC scan, and find out where you really stand:

 Trust your future to Framingham? You're joking - right?

Trust your future to Framingham? You're joking - right?

How about Aortic calcification predicting disaster events? Yep, no surprises - same story. Makes 'cholesterol' risk look like a sick joke:

 Just look at the difference in those survival rates...

Just look at the difference in those survival rates...

Like to see a tiny subset of the CAC /Calcification studies that show how this technology absolutely blows away CIMT and all the other 'risk factors', rendering them redundant? Ok then:

 Yeah - that's why CAC is now enshrined in the US and European guidelines for middle-risk (i.e. most) people. It blows away the other fluff-tests.

Yeah - that's why CAC is now enshrined in the US and European guidelines for middle-risk (i.e. most) people. It blows away the other fluff-tests.

Is YOUR life worth as much as a US president or an astronaut. I'm damn sure mine is. I think yours probably is too. Get a scan, and take action if needed - it ain't too hard to fix the big problems - short video below gives you a primer!

Peter Ballerstedt - Forage Agronomist - on the Ruminant Revolution! #LCHF

Nice chat in Corvallis last night with Peter, who has extensive experience in the science of animal feeding practices - and the subsequent impact on their biological makeup. We cover this, the dietary guidelines debacle, low carb for improving health, and a few other topics ! Note that we do not get into the detail here of particular genetic profiles that may have a sensitivity to dairy and other animal products - this is a more general overview of the field... :-)

Please support this and future 'always free' content, by subscribing to www.thefatemperor.com/subscribe (also for free - of course!)

The graphs referred to on omega 6 / omega 3:

Dr. Ted Naiman and Fat Emperor talk chronic disease: tests and solutions ! #LCHF

Caught up with Dr. Ted Naiman (yes, THE Ted Naiman) in Seattle today, and had a chat on some of the key elements that enable long-term health and longevity. Wondering about the most important blood tests? Ok we talked about those. The ideal diet for the human species? Yep - had a few words. The best diagnostic tests for cardiovascular disease? Yup. What about the most optimum (and yet easiest to do) exercise for your health? Hey, we covered that too - and then some !

Supported by www.IHDA.ie - who work to minimise heart disease mortality in the world.

Please enable further free material release by subscribing at www.thefatemperor.com/subscribe

The mice now speak: Insulin Resistance freed from the confounding of 'cholesterol'

Quick post on some interesting new research sent on to me by Raymund Edwards (thanks Raymund!). Only speed-read it but good to get it out for review. The old cholesterol and atherosclerosis thing has been doing the rounds for decades, while the data points to insulin-related dysfunction being vastly more important. Here we have a team who are helping to remove the 'cholesterol noise' from the insulin picture. I'll simply reproduce Raymund's facebook post in full below. Bottom line is that they've produced a mouse model which separates the 'cholesterol confusion' from the 'insulin resistance imperative'. They have in short demonstrated atherosclerotic acceleration through insulin-mediated action - WITHOUT the cholesterol confounding. Cholesterol metrics gone awry are most often a by-product of insulin/glucose dysfunction, and the 'cholesterol' gets mistaken for cause. So kudos to these researchers - if we had work like this a few decades ago, we might not be suffering the diabetic farce that we are in today...

Don't forget to subscribe for more of the relevant data at www.thefatemperor.com/subscribe

The paper:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891225/ and Raymund's summary excerpts below:

"Some background to this group headed by Sonia M. Najjar
They have a NUMBER of studies planned

--> Individuals with metabolic diseases are at a higher risk of developing atherosclerosis, a leading cause of death in the United States and worldwide.

Earlier studies have linked dyslipidemia to the initiation and progression of atherosclerosis. However, recent clinical studies raised concerns about the efficacy of lowering plasma cholesterol levels in the progression of atherosclerosis. Although insulin resistance is associated with increased incidence of cardiovascular disease, whether it leads to atherosclerosis independently of its accompanying dyslipidemia remains unclear, largely because of the lack of a suitable animal model to address this question.

The CarcinoEmbryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) regulates insulin sensitivity by promoting insulin clearance in liver. Accordingly, global null deletion of Ceacam1 gene impairs hepatic insulin clearance and causes hyperinsulinemia, which in turn, results in systemic insulin resistance.

Preliminary data show: (i) that global Cc1–/– null mice develop early atherosclerotic lesions and vascular dysfunction even under normal feeding conditions, and (ii) that this occurs in the absence of hyperlipidemia, despite VLDL/LDL cholesterol levels that are usually associated with atherosclerosis regression, not development.

This unique animal model of atherogenesis with isolated insulin resistance in the absence of hyperlipidemia demonstrates that systemic insulin resistance resulting from hyperinsulinemia leads to vascular dysfunction and atherosclerosis in the absence of hyperlipidemia.

Because phosphorylation of CEACAM1 by both insulin and VEGF receptors regulates Akt1 activation of endothelial Nitric Oxide Synthase (eNOS), an essential step in mediating endothelial function, it is reasonable to propose that CEACAM1 is the shared downstream element in VEGF and insulin signaling in endothelial cells, whose inactivation impinges upon both pathways and causes endothelial dysfunction in insulin resistance.

==> The CarcinoEmbryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) is a membrane with ubiquitous expression in many cell types, including liver and endothelial cells, but not skeletal muscle and adipose tissue. CEACAM1 regulates insulin sensitivity by promoting insulin clearance in liver.

We and others, have shown that mice with global deletion of Ceacam1 gene (Cc1–/–) exhibit hyperinsulinemia, resulting from impaired hepatic insulin clearance. Hyperinsulinemia in these mice leads to insulin resistance, increased liver triglyceride content and de novo lipogenesis, which drive VLDL-ApoB secretion and triglyceride accumulation in adipose tissue, causing visceral obesity and raising serum fatty acid levels. Thus, the Cc1–/– mouse is a
model of hyperinsulinemia causing insulin resistance.

•• Preliminary data show: (i) that Cc1–/– mice with global Ceacam1 deletion spontaneously develop early atherosclerotic lesions with impaired endothelial-dependent vasodilation under normal feeding conditions, and (ii) that this occurs despite VLDL/LDL cholesterol levels that are usually associated with atherosclerosis regression, not initiation.

Therefore, Ceacam1 deficiency causes hyperinsulinemia and insulin resistance, and promotes lipid-independent vascular toxicity. This makes Cc1–/– a unique animal model of spontaneous
atherosclerosis with isolated insulin resistance in the absence of hyperlipidemia, and provides an in vivo demonstration of distinct CEACAM1-dependent mechanisms linking insulin resistance to atherosclerosis.

• Ceacam1 deletion causes vascular alterations in large vessels

CAC Calcium, the ultimate test for Atherosclerosis...challenges LDL as cause!

Just got hold of a great book, and haven't read much yet. However, you're going to enjoy the initial small excerpts I've collated for your pleasure. Native Human Cholesterol/LDL as a significant causal driver of Atherosclerosis? Never made sense to me to be honest. Data doesn't add up at all. But lookee here at what these guys have dug up - read from the top. Read down...and weep. The book is available here ('Atherosclerosis: Risk Factors, Prevention and Treatment'): https://www.novapublishers.com/catalog/product_info.php?products_id=29530

Warning: This material may cause serious damage...to a lipidologist's peace of mind. Read at your own risk! 

As always for more science scoops, please subscribe (free!) www.thefatemperor.com/subscribe

#LDL Cholesterol - A Nastily Misleading 'Risk Factor' #LCHF

Well here we go again - deja vu. Just looking up some stuff on Free Fatty Acids this evening and came across this paper. These guys made the old mistake of measuring LDL in (a) healthy people, (b) Diabetics and (c) Acute Myocardial Infarction victims. Note that for all groups, patients on lipid-lowering drugs were excluded (i.e. this is a proper study, not confounded with meds). And so we get a glimpse of the fat, sweaty Cholesterol Emperor again. Such careless researchers, to let the cat out of the bag like this! Have a look at what did matter between the different types of people (with LDL at top middle, irrelevant as usual):

And below in tabular form - Red boxes show relevant stuff, while the dashed box shows the junk-science distraction-factor....of the industry darling, LDLc:

But did they call out the LDL irrelevancy in their conclusion, and ask some salient scientific questions? No, of course they didn't. Because you're not allowed to question the LDL dogma, or it's bye-bye to your future funding. That's why we've had to endure the LDLc distraction for decades. And these guys did worse than ignore the obvious LDL question in their conclusion piece. Just look at their actual comments on LDL - what a deceitful joke:

Vinnie Tortorich, Fat Emperor and Dr. Jeff Gerber close with part 3...! #LCHF

Here in part three we wrap that sh"t up!  Book Publishing tips? You got it. Performance athletics with low carb and NSNG? Sure thing. Carb-loading BS - yep we cover that too. And then some... :-)

Please also see Peter Defty / Phinney / Volek seminal work here:  http://www.vespapower.com/the-emerging-science-on-fat-adaptation/

Camera & Sound setup: Dr. Jeff Gerber www.denversdietdoctor.com

Supported by www.IHDA.ie

Please subscribe for free to www.thefatemperor.com/subscribe - for more free content :-)

PART 2 of 3 Below:

And PART 1 of 3 below !

Vinnie Tortorich, Fat Emperor & Dr. Jeff Gerber chat on Malibu Beach - part 2 #LCHF

Here in part two we take off the gloves. "Fat burns in the flame of carbohydrates"? You can lose weight by eating lots of pasta? Medical doctors actually get nutritional training? Who the hell makes up this sh"t - has industry got anything to do with the persistent junk-science? :-)

Camera & Sound setup: Dr. Jeff Gerber www.denversdietdoctor.com

Supported by www.IHDA.ie

Please subscribe for free to www.thefatemperor.com/subscribe - for more free content :-)

PART 1 BELOW - to ease you into it... ;-)

...and final part 3 of 3 below:

Vinnie Tortorich, Fat Emperor & Dr. Jeff Gerber chat on Malibu Beach - part 1 #LCHF

Heeere's Vinnie!

Had breakfast with Vinnie Tortorich and the lovely Serena Scott-Thomas in LA recently. Afterwards we dropped in to Malibu Beach to capture some shenanigans. In part one we get a brief history of Vinnie's troublemaking for the Sugar and Grain industries. We muse on the Diabesity crisis, and wonder how it all went so badly wrong!

Go to www.vinnietortorich.com for more

Camera & Sound: Dr. Jeff Gerber www.denversdietdoctor.com

Supported by www.IHDA.ie

Please subscribe for free to www.thefatemperor.com/subscribe - for always-free content :-)

Part 2 now available below:

...and final part 3 of 3 below:

Dr. Jason Fung and Fat Emperor explore fasting and diabesity - Part 2

Jason doesn't put too fine a point on things, and rightly so - we are living through a public health absurdity, and millions are suffering. Here in part two, we delve deep into the power of fasting. It can quickly resolve fatty liver and T2 diabetes - why aren't people being told we wonder? Jason gets into his stride here, appropriately outraged by the absurdity! Share to help others see the light...

Camera and Sound setup: Dr. Jeffry Gerber www.denversdietdoctor.com

Supported by www.IHDA.ie

( For more free content please subscribe at www.thefatemperor.com/subscribe )

Part one below:

Use the share buttons below as you will... :-)

Dr. Joseph R. Kraft - Stories from the World War II Era - Part 1

On my recent US trip I had the privilege of meeting with Dr. Kraft once more. Father of the Insulin Assay, and one of the most under-recognised greats of medicine and science. Here at aged 95 he talks of old times, relating experiences from World War 2. He was a Medical Captain there, serving mainly in Panama.

He has walked the walk. And he certainly can talk the talk. So how do our modern internet medical gurus compare? What extraordinary history can they relate? What important discoveries have THEY made? Quite.

So please do sit with myself and Dr. Kraft for just a short while. And FEEL the history.

Supported by www.IHDA.ie

Subscribe for free to www.thefatemperor.com/subscribe for more unique content. Always free. Always relevant.

Our July 2015 interview here - on his profound discoveries:

Dr. Jason Fung and Fat Emperor - 'The Fad of Fasting' - Part 1

Dr. Jason Fung gave another great talk at Low Carb USA San Diego. Got to catch up for a chat on camera too. Jason is trying to resurrect for us the superb practice of fasting - the benefits of which have been recognised by ALL of the world's religions for millennia. And rightly so - for metabolic health, neurological health, and to stave off many forms of disease - fasting is one of the best things you can...'indulge in'. I do it all the time - to keep an edge! Here in part one, he introduces the basics. Share this to help counteract our ridiculous 'feed every three hours' corporate culture...!

Camera and Sound setup: Dr. Jeffry Gerber www.denversdietdoctor.com

Supported by www.IHDA.ie

( For more free content please subscribe at www.thefatemperor.com/subscribe )

Part two below:

Use the share buttons below as you will... :-)

WARNING: SALTY LANGUAGE. Those 2 Keto Dudes and Fat Emperor - on Diabetes & KRAFT

Hope you enjoy this podcast on the utter Kraziness of Type 2 Diabetes - and how it could be identified / decimated....decades before those feet have to come off :-(

The following hyperlink has my bit of scientific/engineering outrage expressed reasonably articulately: