Interesting paper today which is rather...revealing. We all want to know what things drive atherosclerosis & heart disease - and here the authors luckily have CAC measurements (the most powerful indicator of atherosclerosis extent - by a country mile).
Sadly they think that atherosclerosis progression can't be stopped - it's an inevitability in their opinion. How sad to see this, how misguided they are - if only they knew. Anyway, on to the paper summary: "Progression of coronary artery calcification seems to be inevitable, but predictable - results of the Heinz Nixdorf Recall (HNR) study"
So what predicted atherosclerosis extremely well then? Let's have a look, shall we?
And what didn't predict atherosclerosis - and in fact could be highly misleading? Have a look below:
Here's the HR's for the various factors - looks like they were too embarrassed to leave ApoB / LDLp in their table (I think you're simply not allowed to criticize this most recent embodiment of the "Cholesterol Hypothesis"):
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