Oh here we go again; I'll never tire of reminding people that Insulin sits at the center of Heart Disease risk, and most other modern afflictions also.
Here are a couple of great papers - the first deals with C-Peptide levels and the Mortality Reality (for 'C-Peptide' read 'Insulin'). The second also deals with C-Peptide, and crosses it with our old friend HDLc; one reason why higher HDLc is good for you, is it tracks with LOW C-Peptide). Of course if you have lower HDLc, but also LOW C-Peptide, that can be cool too - work it out peeps:
The takeaway? Insulin levels as denoted by C-Peptide rule the roost of modern disease - and until these are tackled and lowered, we're beating around the bush with silly cholesterol surrogates. LCHF anyone? Mmmnn yeah.
Excerpt 1: From the first paper, Green line shows the horrendous mortality implications of having higher C-Peptide (even while still retaining ok glycemic control for this 'Group 2'):
Excerpt 2: And from the second paper here's one reason why HDLc being lower is such a predictor of death - it goes hand-in-hand with HIGH C-Peptide levels:
What's wrong with researchers in the Heart Disease arena - do they need their noses rubbed in the Insulin mess like puppies? Root Cause analysis house-training - that's what's needed.
I give up - not :-)