Peter Ballerstedt - Forage Agronomist - on the Ruminant Revolution! #LCHF

Nice chat in Corvallis last night with Peter, who has extensive experience in the science of animal feeding practices - and the subsequent impact on their biological makeup. We cover this, the dietary guidelines debacle, low carb for improving health, and a few other topics ! Note that we do not get into the detail here of particular genetic profiles that may have a sensitivity to dairy and other animal products - this is a more general overview of the field... :-)

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The graphs referred to on omega 6 / omega 3:

Dr. Ted Naiman and Fat Emperor talk chronic disease: tests and solutions ! #LCHF

Caught up with Dr. Ted Naiman (yes, THE Ted Naiman) in Seattle today, and had a chat on some of the key elements that enable long-term health and longevity. Wondering about the most important blood tests? Ok we talked about those. The ideal diet for the human species? Yep - had a few words. The best diagnostic tests for cardiovascular disease? Yup. What about the most optimum (and yet easiest to do) exercise for your health? Hey, we covered that too - and then some !

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The mice now speak: Insulin Resistance freed from the confounding of 'cholesterol'

Quick post on some interesting new research sent on to me by Raymund Edwards (thanks Raymund!). Only speed-read it but good to get it out for review. The old cholesterol and atherosclerosis thing has been doing the rounds for decades, while the data points to insulin-related dysfunction being vastly more important. Here we have a team who are helping to remove the 'cholesterol noise' from the insulin picture. I'll simply reproduce Raymund's facebook post in full below. Bottom line is that they've produced a mouse model which separates the 'cholesterol confusion' from the 'insulin resistance imperative'. They have in short demonstrated atherosclerotic acceleration through insulin-mediated action - WITHOUT the cholesterol confounding. Cholesterol metrics gone awry are most often a by-product of insulin/glucose dysfunction, and the 'cholesterol' gets mistaken for cause. So kudos to these researchers - if we had work like this a few decades ago, we might not be suffering the diabetic farce that we are in today...

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The paper:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891225/ and Raymund's summary excerpts below:

"Some background to this group headed by Sonia M. Najjar
They have a NUMBER of studies planned

--> Individuals with metabolic diseases are at a higher risk of developing atherosclerosis, a leading cause of death in the United States and worldwide.

Earlier studies have linked dyslipidemia to the initiation and progression of atherosclerosis. However, recent clinical studies raised concerns about the efficacy of lowering plasma cholesterol levels in the progression of atherosclerosis. Although insulin resistance is associated with increased incidence of cardiovascular disease, whether it leads to atherosclerosis independently of its accompanying dyslipidemia remains unclear, largely because of the lack of a suitable animal model to address this question.

The CarcinoEmbryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) regulates insulin sensitivity by promoting insulin clearance in liver. Accordingly, global null deletion of Ceacam1 gene impairs hepatic insulin clearance and causes hyperinsulinemia, which in turn, results in systemic insulin resistance.

Preliminary data show: (i) that global Cc1–/– null mice develop early atherosclerotic lesions and vascular dysfunction even under normal feeding conditions, and (ii) that this occurs in the absence of hyperlipidemia, despite VLDL/LDL cholesterol levels that are usually associated with atherosclerosis regression, not development.

This unique animal model of atherogenesis with isolated insulin resistance in the absence of hyperlipidemia demonstrates that systemic insulin resistance resulting from hyperinsulinemia leads to vascular dysfunction and atherosclerosis in the absence of hyperlipidemia.

Because phosphorylation of CEACAM1 by both insulin and VEGF receptors regulates Akt1 activation of endothelial Nitric Oxide Synthase (eNOS), an essential step in mediating endothelial function, it is reasonable to propose that CEACAM1 is the shared downstream element in VEGF and insulin signaling in endothelial cells, whose inactivation impinges upon both pathways and causes endothelial dysfunction in insulin resistance.

==> The CarcinoEmbryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) is a membrane with ubiquitous expression in many cell types, including liver and endothelial cells, but not skeletal muscle and adipose tissue. CEACAM1 regulates insulin sensitivity by promoting insulin clearance in liver.

We and others, have shown that mice with global deletion of Ceacam1 gene (Cc1–/–) exhibit hyperinsulinemia, resulting from impaired hepatic insulin clearance. Hyperinsulinemia in these mice leads to insulin resistance, increased liver triglyceride content and de novo lipogenesis, which drive VLDL-ApoB secretion and triglyceride accumulation in adipose tissue, causing visceral obesity and raising serum fatty acid levels. Thus, the Cc1–/– mouse is a
model of hyperinsulinemia causing insulin resistance.

•• Preliminary data show: (i) that Cc1–/– mice with global Ceacam1 deletion spontaneously develop early atherosclerotic lesions with impaired endothelial-dependent vasodilation under normal feeding conditions, and (ii) that this occurs despite VLDL/LDL cholesterol levels that are usually associated with atherosclerosis regression, not initiation.

Therefore, Ceacam1 deficiency causes hyperinsulinemia and insulin resistance, and promotes lipid-independent vascular toxicity. This makes Cc1–/– a unique animal model of spontaneous
atherosclerosis with isolated insulin resistance in the absence of hyperlipidemia, and provides an in vivo demonstration of distinct CEACAM1-dependent mechanisms linking insulin resistance to atherosclerosis.

• Ceacam1 deletion causes vascular alterations in large vessels

CAC Calcium, the ultimate test for Atherosclerosis...challenges LDL as cause!

Just got hold of a great book, and haven't read much yet. However, you're going to enjoy the initial small excerpts I've collated for your pleasure. Native Human Cholesterol/LDL as a significant causal driver of Atherosclerosis? Never made sense to me to be honest. Data doesn't add up at all. But lookee here at what these guys have dug up - read from the top. Read down...and weep. The book is available here ('Atherosclerosis: Risk Factors, Prevention and Treatment'): https://www.novapublishers.com/catalog/product_info.php?products_id=29530

Warning: This material may cause serious damage...to a lipidologist's peace of mind. Read at your own risk! 

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#LDL Cholesterol - A Nastily Misleading 'Risk Factor' #LCHF

Well here we go again - deja vu. Just looking up some stuff on Free Fatty Acids this evening and came across this paper. These guys made the old mistake of measuring LDL in (a) healthy people, (b) Diabetics and (c) Acute Myocardial Infarction victims. Note that for all groups, patients on lipid-lowering drugs were excluded (i.e. this is a proper study, not confounded with meds). And so we get a glimpse of the fat, sweaty Cholesterol Emperor again. Such careless researchers, to let the cat out of the bag like this! Have a look at what did matter between the different types of people (with LDL at top middle, irrelevant as usual):

And below in tabular form - Red boxes show relevant stuff, while the dashed box shows the junk-science distraction-factor....of the industry darling, LDLc:

But did they call out the LDL irrelevancy in their conclusion, and ask some salient scientific questions? No, of course they didn't. Because you're not allowed to question the LDL dogma, or it's bye-bye to your future funding. That's why we've had to endure the LDLc distraction for decades. And these guys did worse than ignore the obvious LDL question in their conclusion piece. Just look at their actual comments on LDL - what a deceitful joke:

Vinnie Tortorich, Fat Emperor and Dr. Jeff Gerber close with part 3...! #LCHF

Here in part three we wrap that sh"t up!  Book Publishing tips? You got it. Performance athletics with low carb and NSNG? Sure thing. Carb-loading BS - yep we cover that too. And then some... :-)

Please also see Peter Defty / Phinney / Volek seminal work here:  http://www.vespapower.com/the-emerging-science-on-fat-adaptation/

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PART 2 of 3 Below:

And PART 1 of 3 below !

Vinnie Tortorich, Fat Emperor & Dr. Jeff Gerber chat on Malibu Beach - part 2 #LCHF

Here in part two we take off the gloves. "Fat burns in the flame of carbohydrates"? You can lose weight by eating lots of pasta? Medical doctors actually get nutritional training? Who the hell makes up this sh"t - has industry got anything to do with the persistent junk-science? :-)

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PART 1 BELOW - to ease you into it... ;-)

...and final part 3 of 3 below:

Vinnie Tortorich, Fat Emperor & Dr. Jeff Gerber chat on Malibu Beach - part 1 #LCHF

Heeere's Vinnie!

Had breakfast with Vinnie Tortorich and the lovely Serena Scott-Thomas in LA recently. Afterwards we dropped in to Malibu Beach to capture some shenanigans. In part one we get a brief history of Vinnie's troublemaking for the Sugar and Grain industries. We muse on the Diabesity crisis, and wonder how it all went so badly wrong!

Go to www.vinnietortorich.com for more

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Part 2 now available below:

...and final part 3 of 3 below:

Dr. Jason Fung and Fat Emperor explore fasting and diabesity - Part 2

Jason doesn't put too fine a point on things, and rightly so - we are living through a public health absurdity, and millions are suffering. Here in part two, we delve deep into the power of fasting. It can quickly resolve fatty liver and T2 diabetes - why aren't people being told we wonder? Jason gets into his stride here, appropriately outraged by the absurdity! Share to help others see the light...

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Part one below:

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Dr. Joseph R. Kraft - Stories from the World War II Era - Part 1

On my recent US trip I had the privilege of meeting with Dr. Kraft once more. Father of the Insulin Assay, and one of the most under-recognised greats of medicine and science. Here at aged 95 he talks of old times, relating experiences from World War 2. He was a Medical Captain there, serving mainly in Panama.

He has walked the walk. And he certainly can talk the talk. So how do our modern internet medical gurus compare? What extraordinary history can they relate? What important discoveries have THEY made? Quite.

So please do sit with myself and Dr. Kraft for just a short while. And FEEL the history.

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Our July 2015 interview here - on his profound discoveries:

Dr. Jason Fung and Fat Emperor - 'The Fad of Fasting' - Part 1

Dr. Jason Fung gave another great talk at Low Carb USA San Diego. Got to catch up for a chat on camera too. Jason is trying to resurrect for us the superb practice of fasting - the benefits of which have been recognised by ALL of the world's religions for millennia. And rightly so - for metabolic health, neurological health, and to stave off many forms of disease - fasting is one of the best things you can...'indulge in'. I do it all the time - to keep an edge! Here in part one, he introduces the basics. Share this to help counteract our ridiculous 'feed every three hours' corporate culture...!

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Part two below:

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WARNING: SALTY LANGUAGE. Those 2 Keto Dudes and Fat Emperor - on Diabetes & KRAFT

Hope you enjoy this podcast on the utter Kraziness of Type 2 Diabetes - and how it could be identified / decimated....decades before those feet have to come off :-(

The following hyperlink has my bit of scientific/engineering outrage expressed reasonably articulately:

Angela Poff PhD and Fat Emperor discuss: #Cancer and Ketogenic Diets #LCHF #Keto

I really enjoyed Angela Poff's informative talk at Low Carb USA San Diego. I then had the privilege of sitting with her for this short discussion. Anglea has been working with Dominic D'Agostino on the interactions between ketogenic diets and cancer metabolism. Here she covers many key points in this exciting arena !  More details of the superb conference last weekend are at www.lowcarbusa.org - get with the low carb revolution... :-)

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My interview with the famed cancer researcher Dominic D'Agostino at Low Carb USA is below - Angela works with Dominic to help the next generation grapple more successfully with the modern scourge of cancer - we should support them in any way possible:

Want to know if Type 2 #Diabetes is in your future? Okay then. (part 2)

Another fascinating paper on Insulin Resistance measures from Dr. Tommy Wood & http://icelandichealthsymposium.is/foodloose/. The Swedish guys who did this recent study used an exotic lab measurement of IR (euglycemic insulin clamp), as an alternative to simpler Kraft patterns. They called their algorithm 'CEDER'. They had followed 1049 non-diabetic peeps for >9 years, to see how the CEDER Insulin Resistance level would predict diabetes - and CHD. Here's the incidence rate that occurred for the different CEDER IR levels from 1 to 9. Bottom line: a diagnosis of Type 2 Diabetes should never come as a surprise (my graphics added):

2016 Diabetes CEDER Paper.JPG

Unsurprisingly the Coronary Heart Disease plods along in the diabetic wake. With HR's that yet again make an utter joke of the 'cholesterol' metrics. And remember that these guys were only measured for insulin resistance up front in the study - many of the low IR guys would have developed IR over the years, introducing noise into the picture. Which only goes to make the results even more stunning.

 A diagnosis of Type 2 Diabetes should never come as a surprise - nor should the massive heart disease that comes with it.

My earlier post on this diabetic debacle:  http://www.thefatemperor.com/blog/2016/8/6/want-to-know-if-type-2-diabetes-is-in-your-future-ok-then Also, Kraft details discussion here:

 

You can also see the best way to fix the curse of Hyperinsulinemia/Insulin Resistance here:

Kraft killed this nasty hyperinsulinemia/diabetes response rather effectively. He applied LCHF for starters - all the way back in 1972 !! Dr. Joseph R Kraft - a hero without the recognition...

And lookee here at what Prof Gerald Reaven saw, when he used a similar method of IR measurement. Right - it's in here:

http://www.thefatemperor.com/blog/2015/4/30/insulin-resistance-the-primary-cause-of-coronary-artery-disease-bar-none-lchf?rq=insulin%20resistance

And Dr. Jeff Gerber MD / Amy Savigian MD (with a little help from myself) have generated a poster, to expose some of the absurdity - see here:  http://denversdietdoctor.com/challenging-traditional-cardiovascular-risk-assessment/

Why run after 'cholesterol' in ever-decreasing circles, when there are genuinely accurate measures of risk available? When the elephant is in the goddamn room, and staring you in the face? Why indeed.

(The study featured here: "Comparison between indexes of insulin resistance for risk prediction of cardiovascular diseases or development of diabetes" http://dx.doi.org/10.1016/j.diabres.2015.09.003  )

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Dr. Michael Eades and Fat Emperor Part 2 - talking Calcium Scanning & Diabesity #LCHF

Part 2 of my chat with Dr. Mike Eades at Low Carb USA San Diego. Mike decoded the carbohydrate mess way, way back - and is always willing to help anyone with his immense knowledge. In part two, we discuss the power of the Calcium Scan - and the prophetic CAC Score. Also, we muse on causes for our totally insane Diabesity epidemic. Share to help others see the light...note that Calcium Scanning has no equal - see here:  http://www.thefatemperor.com/blog/2016/8/10/repeat-after-me-calcification-score-blows-away-risk-factors-always

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Part 1 below:

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Nick Mailer and Fat Emperor - welcome to Part 2 ! #LCHF

The second part of my chat with the intellectual's intellectual - Nick Mailer ! Here we take the p"ss out of weak hypotheses - well someone has to, eh? Nothing is sacred - all science must be questioned or science is for nought. Okay then - let's do it.

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Part 1 is below, for those who missed it:

 

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Dr. Michael Eades and Fat Emperor talk LCHF Evidence - and Veg Oils...!

Really enjoyed Dr. Mike Eades' talk at Low Carb USA San Diego last week. Finally got to have a chat with him on camera too. Mike decoded the carbohydrate mess way, way back - and is always willing to help anyone with his immense knowledge. Here in part one, we talk about the LCHF evidence base. Also, we touch on the horror of the 'heart-healthy' vegetable oils...! Disclaimer: Mike supported me a lot in the past couple years - but that said, he's still correct in everything.. :-) Share to help others see the light...

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Part 2 on CAC Scoring and Diabesity causes now available below:

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Repeat after me: Calcification Score blows away 'Risk Factors'. Always.

The title says it all - and this study outcome chart. Remember this is all-cause mortality. Not just the cardiac stuff. This is life or death peeps. (RF='Risk Factor' - whether you have none, 1, 2 or 3+ of these, calcium will decide whether they matter):

Here's another view:

Here's yet another study outcome below. There's loads of these available to those who want to look. And they all say the same thing. So how the hell is CAC not used everywhere? I guess they must prefer the muddy statistical noise of their precious 'risk factors'. I guess they must like playing 'risk factor bingo' - with patients lives. Calcium isn't a 'risk factor' - it sees the disease process itself:

So do you wanna play 'risk factor bingo' ?? Be my guest. But you'd better know how to triangulate all those RF's in a seriously expert fashion - engineering-style. And only a tiny number of people can do that. For everyone else there's CAC.  http://circimaging.ahajournals.org/content/5/4/467.full.pdf+html

And what if you don't get a zero CAC score, and are facing a premature visit from the reaper? Don't sweat it - take some action instead. Hit the root causes and you'll likely be ok again. And remember, we ain't just talking heart disease that you'll be averting. We're talking ALL-CAUSE stuff (well, except automobile accidents and the like). You'll be averting Cancer. Diabetes. Alzheimer's. And the rest. Here's a primer:

Get with the program.

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RD Dikeman and Fat Emperor wonder at the Type 1 Diabetes Disgrace...

Shocking content and powerful delivery in RD Dikeman's talk at Low Carb USA San Diego last week. Myself and Dr. Jeff snagged him to talk a little on it. RD set up and leads the fantastic TYPEONEGRIT facebook group, and also produced many video discussions with the great Dr. Bernstein. More details of the superb conference are at www.lowcarbusa.org. Get with the low carb revolution...especially for Type 1 Diabetics ! :-)

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Here's just a tiny taste of the excellent talk he gave on Type 1 and the imperative for LCHF:

A recent comment from RD on this post - the tragedy continues, all over the world -  - just look at those terrifying blood glucose swings (from ~50mg/dL to ~350mg/dL) :

"Just saw this in my feed. So sad"

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