The Empire Strikes Back. Low-Carb & Keto Attacked by...Advertising People?

I received a most excellent cook book from my friend Patricia Daly last year "The Ketogenic Kitchen". It had delicious and nutritious low-carb recipes by the dozen. It also gave a very good overview of the emerging science behind low carb / keto as a healthy and highly nutrient-dense lifestyle. Probably even more so for people suffering from afflictions such as cancer. Low carb would make a lot of sense here - for example see this clip from head of cancer research facility Sloane Kettering Memorial:

So what's the problem? Well apparently some are not happy with sharing scientific progress in interesting new areas. And an advertising agency is taking upon itself the significant task of decoding complex metabolic science. Have a look at this latest shenanigans and judge for yourself - link below:

http://www.irishtimes.com/news/health/advertising-ban-on-ketogenic-claim-stinks-says-domini-kemp-1.3074768

For a good overview of keto and cancer from real experts, see my interviews with Dominic D'Agostino PhD and Angela Poff PhD below - very balanced I thought:

Aseem Malhotra on SKY News - Some real Root Causes of Heart Disease :-)

Aseem Malhotra getting the message out again on SKY News - we've been hoodwinked for generations. Time to redress the balance....!

The recent paper published by Aseem et al here: http://bjsm.bmj.com/content/early/2017/03/31/bjsports-2016-097285

Even the Oirish media are covering it... :-)  http://www.thejournal.ie/saturated-fat-study-medical-journal-3358588-Apr2017/?utm_source=shortlink

Fat Emperor at Weston Price Limerick - a Root Cause Talk #cholesterol #diabetes

Had a great time a few weeks ago at Weston Price Munster event in Limerick, Ireland (www.wapfmunster.com/). Amazing crowd of smart people there - all learning about how a return to "wise traditions" could transform the health of the nation. And the world of course. Big thanks to Anne Maher and the team (Brendan, Deirdre et al) for inviting me down ! Thanks also to Fergal and the guys at Curragh Sound and Vision Studios for recording & expediting the video file to me... www.csvslimerick.com :-) 

In this talk there is some new material, particularly in the first 20 minutes. For the first time at a public forum I share the story of how I got into the health arena. What do YOU know about the blood markers serum ferritin and GGT? Probably about as much as I did in early 2013. If so, prepare to learn a whole lot more....

Supported by www.IHDA.ie - for heart attack prevention awareness

Don't forget to subscribe for free at www.thefatemperor.com/subscribe

Here's me, Anne Maher and the team afterwards on the hallowed turf of Thomond Park (Sam Feltham dropped in from the UK too...!)

Atherosclerosis and Calcification - Important Paper to Review !

I've posted before on some complicated concepts around atherosclerosis progression and calcification. This one is certainly not populist pap for everyone, but crucial for those who wish to understand the deeper mechanisms. Today's paper is from Dr. Scott Murray, a research cardiologist currently operating out of Royal Liverpool University Hospital (the paper is down bottom of the post, after some of my preamble).

First here is a blog post of Scott's which gives an introduction to the value of calcification:  http://www.invasivecardiology.com/blog/Vascular-Calcification-Friend-or-Foe

Here is another post which highlights the problem of assuming we know the mechanisms underlying acute coronary events:  http://www.invasivecardiology.com/blog/unveiling-evanescent-chameleon-%E2%80%94-true-risk-coronary-plaque-can-only-be-determined-prospectively

However, the primary paper for atherosclerosis and plaque property insight is linked at the end. It greatly improved my understanding of what is really happening in "vulnerable plaque". And how calcification metrics play into it. Scott and the team used vascular ultrasound to scrutinize the plaque properties in detail. They then created new mathematical constructs to quantify "vulnerability level" of the plaque. To say that it resonates with me is an understatement. Also, it explains why the "density versus volume" part of the CAC score (from a simple CT scan) can be so important to analyse.

To grossly simplify, a person who has high density for a given plaque volume in the CAC, would likely on average get a desirable score in Scott's modeled variables of vulnerability. They would likely have a higher plaque calcification equipoise (PCE) and a lower calcified interface area (CIA) in general. Thus Scott's work may bridge the local mechanistic physics of vulnerable plaque, to the prognostic power of the CAC score - especially when the latter is examined for the interplay of both density and volume.

Confused? That's ok - read the below paper again, and link the insights to what I've discussed before here:   http://www.thefatemperor.com/blog/2017/3/3/dr-mike-eades-important-note-on-calcification-volume-vs-density-cac .

Really confused? Don't worry - just ping Scott, Mike Eades, Jeff Gerber or Gearoid O'Laoi - and they'll explain it all to you ! But first internalise Scott's fascinating paper at the link below !!

Site-specific intravascular ultrasound analysis of remodelling index and calcified necrosis patterns reveals... 

Gallup Strengthsfinder - A seminar to help you identify your strengths ;-)

And now for something completely different. It's true that #LCHF, fasting and good nutrition will enhance your overall and indeed career performance. But there are other tools too. If you are interested in maximizing your personal strengths, here's a seminar I gave recently on the topic. Gallup Strengthsfinder is a powerful tool. You can take the survey and access some excellent analysis at:  https://www.gallupstrengthscenter.com/
Over 15 million people have taken part. I highly recommend it for personal self-awareness - and career optimization !
Note 1: I have no connection to Gallup, and no financial interest in this matter. I may however be available to give similar seminars, if the incentive was appropriate...  :-)  Note 2: The sound is poor for the audience inputs - didn't have a dedicated mic... :-(

Ireland National Wellbeing Day 31st March - what are they telling us? #LCHF?

Ok you couldn't make it up. So I didn't. National Workplace Wellbeing Day arrives on March 31st. What will stem the enormous tide of diabetic dysfunction based on previous dietary advice? Well let's take a look. 

Document can be downloaded here:  HEALTHY KIDS DIETARY GUIDE

Some excerpts below. Carb-up with insulinogenic Holegrains? and decimate the healthy evolutionary fats in our diet? Perfect fuel to prime the pump...for a metabolic syndrome future. The pyramid first - as for the past 40 years, so it continues:

...and it appears that our children have transmuted into little horses:

...looks like they are certainly not a species descended directly and proximately from hunter-gatherer tribes:

Just in case you inexplicably didn't get the main message:

For correctly interpreted science updates, subscribe for free at:

http://www.thefatemperor.com/subscribe

Fat Emperor and Weston Price's Anne Maher on Limerick 95FM Radio #LCHF

Nice little chat this morning on Limerick's finest radio station - myself and Anne covered ancestral foods, what to eat, what NOT to eat - and a few more interesting things. I'll be speaking at this year's Weston Price event at the weekend with many others - Oirish peeps would do well to come along! The interview:

https://www.live95fm.ie/on-air/shows/limerick-today/limerick-today-podcasts/march-2017/limerick-today-wise-traditions-is-the-knowledge/?platform=hootsuite

The upcoming event - get in there! : https://wapfmunster.com/

The interview here also in case above link doesn't work across the world:

Fat Emperor Limerick 95FM

Cardiovascular Discussion - and Debate - in London October 2017 #LCHF

A most interesting and prestigious event will be taking place in London later in the year. It is being run by the British Association for Cardiovascular Prevention and Rehabilitation (BACPR). Welcome will be cardiologists, doctors, nurses, nutritionists and even knowledgeable members of the public. Link below:

http://www.bacpr.com/pages/news_box.asp?NewsID=19495696

Interestingly, a debate has also been mooted, relating to some element of cardiovascular or obesity treatment controversy.

The "Pro" side will have representation from the UK's medical establishment. And it appears that the "Con" side has also been chosen I believe. This person would want to be sure of the science, if going against the accepted orthodox approach. That would be a minimum requirement, wouldn't it?

I wonder who this person might be?

The 2017 conference sessions will include many fantastic speakers, some of whom will be familiar to many LCHF people across the world:

·         Dr Aseem Malhotra: Choosing Wisely

·         Dr David Unwin: Revolutionizing Diabetes Care

Subscribe for free at www.thefatemperor.com/subscribe

Supported by www.IHDA.ie - the Irish source for crucial information...on identifying Heart Disease early enough to prevent Heart Attacks

Excellent Metabolic Science Podcasts from Gabor Erdosi and Raphi Sirt #Diabetes

UPDATE 12th March: Episodes 2 to 6 now released!

http://breaknutrition.com/breaknutrition-show-episode-2-guest-speaker-gabor-erdosi/

http://breaknutrition.com/breaknutrition-show-episode-3-guest-speaker-gabor-erdosi/

http://breaknutrition.com/breaknutrition-show-episode-4-guest-speaker-gabor-erdosi/

http://breaknutrition.com/episode-5-enlarged-adipocytes-overloaded-lipids-lead-insulin-resistance/

http://breaknutrition.com/why-bariatric-surgery-improves-metabolic-parameters-quickly/

Gabor Erdosi has a masters in molecular biology. Raphi Sirt is also a biochemistry graduate. Importantly, they are expert problem-solvers, with engineering brains. They can decode the complexity - and get to the inner workings of the human machine: Diabetes. Fatty Acid and Glucose metabolism. Insulin Resistance and Hyperinsulinemia. And the rest.

Warning: these podcasts are superb discussions, each centring on a particular scientific study of great interest. But in fairness they are not really intended for the layperson. However, they are excellent for the more biochemically-versed individuals - who wish to understand how it REALLY works ! Chat to them by joining the Lower Insulin Facebook group:  https://www.facebook.com/lowerinsulin/

...and don't forget to subscribe to www.thefatemperor.com/subscribe !

Please access these and more excellent podcasts by clicking below image:

The RCT's said PUFA was NOT better than SAT Fat. And so they buried the results...

Polyunsaturated oils lower your "cholesterol" - true. And this supposedly should lower your heart disease and death rate? Oops - false. Rather embarrassing for the defenders of the risible Diet-Heart Hypothesis.

And the early Randomized Control Trials (RCT's) that showed up this sweaty naked "cholesterol" emperor for what he really was? They disproved the rsilly hypothesis. So they had to bury the results, didn't they. How naughty - even before they could think up a reason for the failure. Lies of omission, lots of them.

The morons of course then retreated into the grossly misleading epidemiological junk-science. We've seen mountains of this stinking manure, desperately propping up a rubbish hypothesis. These nefarious efforts have doomed the population to continued ingestion of the revolting seed-oils. Have they no shame? Have a read of this 2016 article here, which summarizes the debacle (click the image below for paper): 

Subscribe to www.thefatemperor.com/subscribe - for real science, not fake epidemiological claptrap.

Oh, and below is the master Masterjohn on the topic:

What things properly predict Atherosclerosis extent? Have a look !

Interesting paper today which is rather...revealing. We all want to know what things drive atherosclerosis & heart disease - and here the authors luckily have CAC measurements (the most powerful indicator of atherosclerosis extent - by a country mile).

Sadly they think that atherosclerosis progression can't be stopped - it's an inevitability in their opinion. How sad to see this, how misguided they are - if only they knew.  Anyway, on to the paper summary: "Progression of coronary artery calcification seems to be inevitable, but predictable - results of the Heinz Nixdorf Recall (HNR) study"

So what predicted atherosclerosis extremely well then? Let's have a look, shall we?

Whoa - big prediction here - very important things to watch - the higher they are, the more atherosclerosis - never fails !!! Note that diabetic physiology underpins most cardiac disease - and idiopathic blood pressure is mostly hyperinsulinemia driven. Go figure ;-)

Whoa - big prediction here - very important things to watch - the higher they are, the more atherosclerosis - never fails !!! Note that diabetic physiology underpins most cardiac disease - and idiopathic blood pressure is mostly hyperinsulinemia driven. Go figure ;-)

And what didn't predict atherosclerosis - and in fact could be highly misleading? Have a look below:

Bum steer there guys..."Cholesterol" can be good when it's low - and bad when it's low too! Don't go by these measures...note around 17% of the super-high CAC group were on Lipid-lowering, versus ~14% of the very-high CAC group - so the poor predictability of "cholesterol" wasn't due to that factor... ;-)

Bum steer there guys..."Cholesterol" can be good when it's low - and bad when it's low too! Don't go by these measures...note around 17% of the super-high CAC group were on Lipid-lowering, versus ~14% of the very-high CAC group - so the poor predictability of "cholesterol" wasn't due to that factor... ;-)

Here's the HR's for the various factors - looks like they were too embarrassed to leave ApoB / LDLp in their table (I think you're simply not allowed to criticize this most recent embodiment of the "Cholesterol Hypothesis"):

Don't forget to subscribe for free at www.thefatemperor.com/subscribe - unless of course you prefer fake news... ;-)

Calcium Scanning for Younger People - still amazingly powerful ! #CAC #cardiovascular

Covered a VERY recent study in my #LowCarbBreck talk last week. Kind of shocking really.  CAC is an incredible test for middle-aged middle-risk people, the group where most heart attacks occur. Now there is a rather deceitful and misleading argument against CAC - that it may give "false negatives" for younger people (i.e. show a low score but they still have significant danger). There are so many reasons why this is essentially misleading, and statistically not so relevant - but here are a couple:

1. Overwhelmingly, heart attacks occur in middle-aged or older people. The younger people are a tiny fraction of the actual problem (not that they aren't important mind). This argument is used to push back against CAC generally. Naughty. 

2. The "false negatives" are from people who got a low score yet went on to have an event a few years later (I still haven't got this data but that's what "they" say). However, younger people whose diabetic fires are blazing will need more regular scans if they don't fix the underlying problem. Example: They get a zero/low CAC at say, year zero. They would have had a higher score at say, year one (but didn't get a scan - oops). Then they have an event at say, year two. This isn't an argument against CAC - it's just an unreasonable demand placed upon the technology !

Anyway, now to the paper. Looks like the argument is more misleading than I thought. See slide below - the CAC is massively predictive for younger people - even with lowish "risk factors" present ! Just look at the predictive power here using a CAC scan - absolutely amazing - nothing comes close. Why am I not surprised?

Go to www.IHDA.ie for more info on CAC, and see the super Widowmaker Movie by clicking below (with Gillian Anderson and a host of genuine cardiovascular experts :-) :

And please SUBSCRIBE (for free of course) at:

www.thefatemperor.com/subscribe

Dr. Mike Eades - Important note on Calcification Volume vs Density. #CAC

Great panel discussion at Low Carb Breckenridge. Here Mike Eades clarifies an important note around the CAC score. While it is the most powerful test for cardiac and all-cause mortality prediction (by a mile), there are some nuances.
Specifically the Volume component of the CAC score is important to scrutinize (the CAC score has both a Density and a Volume component). If you have a high score where Density dominates over Volume, your risk may be ok. If your score advances over the years, dominated by density (with volume falling) - you do not have appreciable risk. The worst case is where Volume dominates over Density - this is a major flag for unstable plaque presence.

The paper Mike notified me of some time back, is very revealing in this context:

LINK: Calcium Density Versus Volume Paper

See The Widowmaker Movie (2015) here - a fascinating docu-drama showing where the cardiovascular world went so disasterously wrong !  https://vimeo.com/201445705

In the following clip, Mike explains the nuance most eloquently! Discussion in more detail at end of this post

The power of CAC illustrated in one of my earlier posts - click the image below to gain the insights! :

The Widowmaker Movie - click below to watch for a dollar :-)

This arena is nuanced indeed. You do divide the Overall score by the (volume/2.5) to get the density number, but it is a tricky one e.g.:

- If your Agatston value is very low, even with low density quotient - you are in ok shape - but only because these low density guys are  "Low overall score" guys (they have little plaque, and it ain't too calcified - but they have little burden anyway so ok).

 - If your density value is high you may also be in ok shape - these high density guys have high overall scores, but are protected by their relative density - lots of plaque, but nicely consolidated with Ca - nature is working well for them.

- the problem guys are the ones with high score and high volume - these have high plaque burden and it is not stabilized adequately by nice dense calcification !

The secret is buried in this table:

Someone with a high overall score, but high in density - is at similar risk to the average guy who has a CAC score of around 20. See above on the "density" line - the guys with high CAC (Agatston) scores in right hand column have an average density of ~3.5 and their risk thus begins to sharply fall off, making them like Agatston=20 scorers.

It's a tricky one for sure, kind of a hyperbolic relationship with two vectors involved - overall score versus density quotient.

AND NOW THE PLUMBING ANALOGY:

Explained it to my daughter who is going for medicine in college. Imagine buildings with corroding pipes:

1. Some buildings have small pockets of corrosion, but it is not really patched up much by the plumbers - they have lowish risk of flooding. (low CAC score, low volume score, low density peeps).

2. Then there are buildings with a lot of corrosion all over the system - but great plumbers have patched up all the weak areas (high CAC score, low volume score, high density peeps).

3. Then there are the shitty buildings - they have lots of corrosion all over, but crap plumbers who have not patched up very well (high CAC score, high volume, low density peeps). The latter need to get good plumbers in fast....or to go #LCHF asap !!!!

(p.s. the last guys (3) are generally poorly-controlled diabetics - corroding fast before their tattered systems can shore up the damage) 

Dr Jeffry Introduces Dr. Junesang Yang (Low Carb Hero) from Korea !

Dr. Jeffry Gerber finally gets to meet his family doctor colleague and friend Dr. Junesang Yang. June has single-handedly brought #LCHF to south Korea by translating Robert Lustig MD's YouTube lecture https://www.youtube.com/watch?v=dBnniua6-oM and Nina Teicholz's book The Big Fat Surprise: Why Butter, Meat & Cheese Belong in a Healthy Diet into Korean.

Dr. Yang has appeared on national television documentaries featuring low carb. What he calls his 'rogue' research has now brought low carb to tens of thousands within his country! Keep up the great work Dr. Yang :-)

http://enews.imbc.com/News/RetrieveNewsInfo/192998

A subsequent more detailed commentary from June below:

Hello everyone
I am June Yang
A family medicine doctor in korea
Thank you for an opportunity to speak Dr Jeffrey Gerber
It was the first time speech in english after graduation. I was too nervous.
What I wanted to say was as follows :

Actually I am not good at english. But I hope to communicate with you. 
Because I can communicate with japanese people though I can barely speak japanese.
Let me talk about my story.
When I was in my medical residency,
One of my friend who was very smart and very muscular told me that whenever you don't eat foods your body is being destroyed. You may want to eat just after awakening in the morning and just before going to bed. 
I think you have heard this wrong nutiritional knowledge. 
Then I started eating all the time.
Korean people have eaten so much more than other people in the history of far east. 
They ate so much whenever there is food. 
I was able to eat so much quantity.
I got bigger and bigger with the fatty liver disease.
My blood triglycerides had been above 200 for many years. My liver enzyme ALT went up over 50.
In 2013, I knew that the saturated fat is not bad through the mercola.com.
I started to eat low carb high fat with intermittent fasting. Actually, I had been skipping breakfast for previous 2 years, but it was not sufficient.
I lost 7kgs in 2weeks. 
My triglycerides went down below 100 immediately. 
My irregular heart beat from which I suffered for years was gone.
I talked about low carb high fat to other doctors. You can imagine their responses.
It was cold and indifferent. 
I was frustrated and stopped talking. 
Instead, I have studied all alone. I analyzed korean national health and nutrition examination survey. And I found that the women who eat more fat are healthier than less fat eaters. I uploaded my findings on my blog. Last year somebody published similar findings on a medical journal.
On the other hand, I translated Robert Lustig's lecture at UCSF which recorded more than 7 million views in youtube. People can read his lecture in korean language on my blog. I am a translator who can barely speak english. 
And, I have been blogging about Proper nutrition.
In august 2014, the big fat surprise written by Nina Teicholz was published in the united states. As soon as I read that book, I decided to tranlate it into korean language. It was published April 2016.
Finally, people got interested in my efforts.
There are more than ten thousand followers in my Instagram. They are giving me many ideas.
Now I believe tens of thousand people in korea are living on a low carb high fat diet.
Many people have been improved or cured from obesity, diabetes and other illnesses in the short period of time.

Korea has carnivore tradition. 
Bone broth is widely popular food. There are so many kinds of bone broths in korea.
Sometimes korean People eat even cartilage, bowels, lung, heart, liver and kidney. 
There is a good enviroment for low carb high fat diet.
I watched the lectures from the lchf convention in South Africa 2015 again and again.
I read books written by Jason Fung, Stephen Phinney and Tim Noakes. 
I Thank so much to you Low carb people here.

Last year, 6 medical and nutition academies in Korea simultaneouly announced the statement against low carb high fat diet. They quoted Ancel Keys.

Recently I analyzed korea national health and nutritional survey data. 
I decided to publish on a medical journal with Jeffry Gerber
Because I was inspired by him, Thank you again Dr. Jeffrey Gerber.

I am in honor of being here wih my heroes, now.
I hope to communicate with you continuously in the future. Thank you so much.

Deep-dive time - if you want to know the deeper mechs of Insulin versus cholesterol

Physician's for Ancestral Health have just released my talk from their Miami Retreat last month. You want to go a little deeper on the mechanisms of Hyperinsulinemia/IR? Ok then - here you go.

With special thanks to Gabor Erdosi of the Lower Insulin facebook group - he has single-handedly decoded the early stages of this universal dysfunctional state. Yep folks - It all starts in the adipose tissue!

Supported by www.IHDA.ie - see the superb Widowmaker Movie here for a mere dollar !  https://vimeo.com/201445705

Dr. Joseph Kraft passed away today - Rest in Peace.

I have just heard the sad news that Joe passed away today at 95.

His level of achievement was huge, though disgracefully under-recognized. He was a pioneer in understanding how to avert the looming iceberg of diabetes, discovering the earliest laboratory diagnosis for the disease in the 1970's. He tried to warn the world - but the world would not listen. We are now seeing his prophecy come true. He was a great inspiration to myself and Dr. Jeff Gerber since we discovered his work and interviewed him in 2015. It was a great day for us, and we got to meet up there with another insulin expert who truly appreciated Kraft's work - Dr. Ted Naiman.

Rest in peace Joe. Your work will continue to be spread around the world. Sincerest condolences to Kevin and Joe's extended family. They should all be extremely proud of what he has achieved.

"Plenus annis abiit, plenus honoribus"

For myself, I will always remember Joe, just as he was in our last meeting:

The full interview covering Joe's work is below, recorded in Chicago in the summer of 2015 

Look who just showed up on Mercola.com - Cholesterol Vs True Root Causes!

Click on pic below for the post. Insulin ain't everything, as I clearly point out in my talk. But most "cholesterol" or "dyslipidemia" problems are only a manifestation of insulin/glucose dysregulation. There are many other causal agents for heart disease too - it is of course multifactorial. But running after cholesterol is a rather silly strategy. Do as an informed engineer would do - focus on the primary drivers !

Myself and Dr. Jeffry Gerber (http://denversdietdoctor.com/) will have a book coming out late in 2017 with this and much more analysis of how to live long - and with healthy vitality to the end!

And if you want to know your extent of heart disease, before tackling the causes? You can watch the referenced "The Widowmaker Movie" at this link - to understand the history and power of the calcification score (CAC). This can be got from a simple 5-minute scan which is grossly underused at present: https://vimeo.com/ondemand/thewidowmakermovie2015/201445705

But on to the Mercola post - click image below... :-)

My Interview with the man behind Mercola.com - Dr. Joseph Mercola

Sharp, intense and extraordinarily accomplished - Dr. Mercola has built a huge empire in the alternative health business. Does he have non-orthodox and controversial ideas about health and longevity? Of course. Preview of our interview here to get a sense of the individual Sign up to http://www.dietdoctor.com for the full discussion - and a lot, lot more !

Excellent Metabolic Science Podcasts from Gabor Erdosi and Raphi Sirt #Diabetes

UPDATE 18th Feb: Episode 3 released today - get the others below first, but here it is ! http://breaknutrition.com/breaknutrition-show-episode-3-guest-speaker-gabor-erdosi/

Introduction: Gabor Erdosi has a masters in molecular biology. Raphi Sirt is also a biochemistry graduate. Importantly, they are expert problem-solvers, with engineering brains. They can decode the complexity - and get to the inner workings of the human machine: Diabetes. Fatty Acid and Glucose metabolism. Insulin Resistance and Hyperinsulinemia. And the rest.

Warning: these podcasts are superb discussions, each centring on a particular scientific study of great interest. But in fairness they are not really intended for the layperson. However, they are excellent for the more biochemically-versed individuals - who wish to understand how it REALLY works ! Chat to them by joining the Lower Insulin Facebook group:  https://www.facebook.com/lowerinsulin/

...and don't forget to subscribe to www.thefatemperor.com/subscribe !

Please access these excellent podcasts at:

http://breaknutrition.com/

 

If any issues the first podcast, focussing on this paper:  http://www.ncbi.nlm.nih.gov/pubmed/25662011

The follow-on podcast, focussing on this paper:  http://www.ncbi.nlm.nih.gov/pubmed/20943748