Prof Tim Noakes at Foodloose Iceland - Driving The Revolution #LCHF #Diabetes

Super to catch up with Prof Tim Noakes, following his excellent talk at the Foodloose event. Here we discuss the challenges of LCHF leadership, and how to stem the tide of Diabesity. This will only be achieved through the appliance of correct nutritional science. But how does one overturn the many misled professions? Recorded at the May 2016 Foodloose Iceland event (Harpa Conference Centre, Reykjavik).  http://icelandichealthsymposium.is/foodloose/

Over 7,000 views in a little over a week - don't miss it...! #LCHF #Cholesterol #Diabetes #Insulin

Proving popular, and it should be. 'Cholesterol' put in its place, and the real worries for a shortened lifespan clarified. Plus details of the best test of all, to flag the fire inside. Most importantly, how to calm the flames, and live long & strong ! Don't forget www.thefatemperor.com/subscribe for free, to keep the pipeline full... :-)

Heart Disease Prevention & More - Widowmaker Full Q&A Session #LCHF

Complete edited Q&A footage recorded at the May 11th Dublin Cardiovascular Dublin event. The discussion was quite heated at times - and rightly so ! Watch us hit some home truths on Heart Disease, LCHF, Diabetes, The Food Pyramid, Statins, Fats, LCHF, Obesity, Diabetes, Vitamin D, A and K2, Sugar and the WHO - and much, much more ! As always, please support this free content by subscribing at www.thefatemperor.com/subscribe - for more free content as it becomes available.       "SHOW ME THE DATA !"

Context-setting talk:

Q&A Part 1/3 :

Q&A Part 2/3 :

Q&A Part 3/3 :

ENJOY !!!

Heart Disease root causes - Sparks Fly in our Q&A Session Part 1 ! #LCHF

First Part of Q&A recorded at the May 11th Dublin Cardiovascular Dublin event - excerpt from the two-hour Q&A session 8pm-10pm. The discussion was quite heated at times - and rightly so ! Watch us hit some home truths on Heart Disease, LCHF, Diabetes, The Food Pyramid, Statins and much more !

PERHAPS BEST TO FIRST ENJOY my hard-hitting introductory talk BELOW - no punches pulled - don't miss it:

Heart Disease root causes - and the tests that can save your life ! #LCHF

My talk recorded at the May 11th Dublin Cardiovascular event, prior to the free screening of The Widowmaker Movie. Event organised by Alan Crean of DCU, sponsored by David Bobbett and the www.IHDA.ie team - and a great night it was too! Soon to follow will be footage of other content including our superb Q&A panel, who had answer audience questions for 2 hours - highly engaging discussions :-)

We had around 200 people in this excellent lecture theatre - not bad for an event starting at 6pm on a Wednesday evening :-) The punters got a lot of value out of the 4-hour session I think. Further material to be released includes introductions, an impassioned talk by David Bobbett, a cardiovascular intro by cardiologist Ross Murphy - and excerpts from the two-hour Q&A session 8pm-10pm. The latter became quite heated at times - which is the way I like it...! First to be released is my introductory talk - I hope you see fit to share widely. We all need to be talking about this. We really do.

The lineup and details of the superb guys who comprised our Q&A panel is in this link:  https://www.eventbrite.ie/e/dcu-widowmaker-screening-tickets-24027733598
 (Professor of Cardiology Sherif Sultan got called to an emergency case, and sadly we missed his presence - but we'll get him next time!). Question and Answer Session below - we don't pull punches in Ireland, oh no:

Best

Ivor

Chat with neurotologist Dr. Kenneth Brookler MD #Insulin #LCHF #Diabetes

Dropping by New York I took the opportunity to have another enjoyable chat with Dr. Brookler. Since our last meeting, he has been focussing in on the clinical effects of low-carb, high-fat diets. He is seeing some impressive outcomes from the approach !
He has also been researching insulin's effects on endoplasmic reticulum stress, particularly that in the beta cells of the pancreas. It speaks to the mechanisms by which hyperinsulinemia wreaks havoc, leading to the chronic diseases of the insulin resistant state. Enjoy, and subscribe for free to:

www.thefatemperor.com/subscribe

..this will deliver future content (always free). In fact, very shortly we'll have another great conversation with Professor Richard Feinman - on the key details of his cancer research with Professor Eugene Fine...!

#LCHF Latest Podcast with @VinnieTortotich - no Punches Pulled...!

Well, Vinnie asked to do a bit of a re-run of the Cholesterol-focussed podcast from way back last year. His audience has got a lot bigger, so new peeps to run the basics by. Pull no punches was the brief - no dancing around the data. Why not call it out for the 50-year farce that it has been? Ok then - gloves off - out with it !  :-)

http://vinnietortorich.com/2016/04/ivor-cummins-and-the-cholesterol-conundrum/

#LCHF #cancer An Interview with Dr. Peter Attia - very good. #KRAFT reference at 18m30s !

Thanks to David Wynnt for sending this one on ( @wyadvd on twitter ). Very good discussion, and I loved his one key test for longevity that anyone can get. Yes, it's the old Post-Glucose Insulin - which he says should be below 30uIU/ml. Exactly as Kraft discovered many decades ago. It's not just cardiovascular disease guys - it's cancer too. And diabetes of course. And neurological degeneration. And...well you get the point. it's healthy longevity !!

Petition to Reinstate Nina Teicholz to Food Policy Panel ! #LCHF #Diabetes

Ok the petition is doing well at 1,500...well at 3264 signatures now I see, after a couple more days... Keep them coming. Please help to share widely. The nutritional guidelines ARE important - and they must have proper scientific debate before being foisted on millions:

#LCHF #keto The Story of Jeff Cyr. You would do well to read it. And to tell your doctor.

I reproduce in full here one man's experience with discovering low carb living. And not a day too late. Original blog post here: http://zerocarbzen.com/2015/09/16/how-a-high-fat-ketogenic-diet-saved-my-life-by-jeff-cyr/ The story is reproduced in full below.

How a High Fat Ketogenic Diet Saved My Life by Jeff Cyr

 

Editor’s note: Jeff is not 100% Zero Carb. He does eat 10-15 grams of carbs per day from cucumber, radish, and spinach. He also consumes coconut oil which most Zero Carb practioners do not do because it it from a plant. Jeff’s diet is 85% fat from meat, butter, and coconut oil. He eats only 75 grams of protein per day. In spite of these differences from a standard Zero Carb diet, I felt his story was too inspiring not to share. May it reach those who most need to hear it.

In Jeff’s words…

I realize some of you here have already seen these pictures of me and have read my story before. My only intend in re-writing this short story on what a ketogenic diet has done for me is to maybe give hope to some of you out there that may think there is no way out of your current situation. To maybe show you that no matter how bleak your situation may seem right now that there is a way out. I realize that following a ketogenic diet may seem a bit extreme to some of you. Some of you may be here to try and find out more information on what exactly is a ketogenic diet and what can it really do for you. Hopefully once you have read this short story some of you may be willing to give this a try. And who knows some of you may even save your own lives the way I have saved mine.

I firmly believe I was born with a pre-disposition to insulin resistance. I was always overweight as a child and at the age of 17 I weighed 345 pounds. We were always taught to eat a high carb based diet and to never eat fat or cholesterol. I went on many diets during a 30 year span I must have lost 100-130 pounds on at least six different occasions always regaining all what I had lost and a little bit more. Those of you that have seen pictures of Butter-Bob Briggs on his website were he has a picture of himself with no shirt on at his biggest size this is also a picture of me. Only difference is I was like that at the age of 17. I wore size 48 waist pants and 3xxl shirts.

I am going to start this story back in October of 1997. I was rushed to a hospital in southern Maine where I found out that they had to preform an emergency surgery on my lower back. I was diagnosed with severe lumbar spinal stenosis. The neurosurgeon had to preform what is called a laminectomy and fusion of the lumbar area(low-back) L-3 L-4 L-5 L-6 with titanium rods and screws. I had been in pain from my lower back for a very long time, for the last year before the surgery, I could barely walk but I had to keep on working as I had no health insurance. I found out after that buy waiting so long for the surgery that I had done a lot of permanent nerve damage from the waist down.

Fast forward to May of 2001. From an injury that happened at work I had to have what is called a cervical neck fusion. I had ruptured 3 disks in my neck area C-4 C-5 C-6 so the same neurosurgeon performed a cervical neck fusion with bone marrow in place of the disks and fused with a titanium plate and screws. And then in January of 2004 came the final blow. From another injury at work I needed another back surgery. This time it was the mid-back(thorasic) The same neurosurgeon performed a laminectomy and fusion of T-11 T-12 with titanium rods and screws. After this final surgery I was declared permanently and totally disabled by the Doctors and the workers compensation board. I was 44 years old.

Then in April of 2005 I had to go in for hernia surgery. They had to do routine blood work before the surgery This is when I got the diagnosis of type 2 diabetes. I had a fasting blood sugar of 300 and an A1C of 12.0. The doctor put me on metformin and avandia and blood pressure medication and proceeded to tell me “Welcome to the club you’ll probably have to be put on insulin in a few years. And yes he also send me to a diabetes nutritionist who fed me the typical high-carb diet whole grains fruits etc.

After my first back surgery back in 1997 I was put on pain medication. After time I was prescribed more hard core drugs eventually ending up on oral morphine in high doses. Also from all these different surgeries and fusions i was left with not very much mobility. I weighed 330 pounds and pretty much was confined to a lazy boy recliner 24-7. I was not able to lay in a bed to sleep. I had to sleep in my chair. I had to walk with a cane or a walker only very short distances. If I went to any store I had to use the motorized handicap chairs. This was especially humiliating the stares you get from people as you drive buy them in your motorized cart. This pitiful life went on like this for a while but change was coming.

In November of 2008 is when when my life started slowly to turn around. I had felt sorry for myself long enough it was time for something different. The first thing I did was to quit smoking cold turkey. I started smoking at the age of 16 and the last 10 years I had been smoking 3 packs a day. After 2 months had gone by I stopped oral Morphine cold turkey without consulting my pain management doctor. The withdrawals you hear people speak of from heroin are the same with oral morphine. These withdrawals lasted 3-4 weeks. Then in April of 2009 I started riding a recumbent stationary bike at the gym. I went on another diet and started slowly losing weight. In the span of 14 months I went from 330# to 167#. Thats a total weight loss of 163 lbs.

You would think I was Healthy now, right? I thought I was my doctor even told me I no longer had diabetes! My A1C was 5.9% and this led my doctor to telling me that I no longer had diabetes. At this point I was still clueless! Still clueless that an A1C of 5.9= an average blood sugar of 133. Clueless as to the level of insulin resistance inside of me. Clueless that by following the standard ADA recommendations I would have constant high blood sugar and high insulin levels floating in my blood stream. And also clueless that a weight of 167 was NOT healthy for me. I had lost body fat but during this weight loss journey I also lost a lot of muscle and bone density. Some of you may be wondering muscle and bone density? The short answer to this is when one is not fat-adapted you are still primarily a sugar burner. Problem is being a type 2 insulin resistant diabetic you can`t use glucose very well so your liver ends up taking amino-acids from your muscle and bone to maintain what is called glucose homeostasis.

Then in November of 2011 everything changed in my life you could say everything came crashing down. After a series of blood work -ultrasound-cat scan and finally a liver biopsy I was diagnosed with an auto-immune fatal liver disease called primary sclerosing cholangitis. This liver disease attacks the bile ducts of the liver slowly plugging up the bile ducts where bilirubin and bile can no longer get through. This eventually causes cirrhosis of the liver leading to total liver failure. The only cure would be to get a liver transplant. I was told all this by my liver doctor and told that once diagnosed people live on average 8-10 years. Told there was no medicine nothing could be done. I suppose He was expecting me to go home sit down in my lazy boy and wait to die.

This is when I started doing research on line and one thing led to another. I started with auto- immune diseases this somehow led me to Dr. Ron Rosedale. This for me is what got everything started for me as far as educating myself on what you put in your mouth. How changing the macro-nutrient composition can change everything. I read everything I possibly could find watched every video that I could find online. Then I started researching Dr. Steve Phinney and Dr. Jeff Volek. I was so intrigued by this ketogenic diet I had to learn everything I possibly could. This led me to a lot of experts on this subject and I soaked everything up like a sponge. I still continue to learn about the ketogenic diet and its many benefits.

In my former life of employment, I was a machinist-metal fabricator-welder. So the way my mind works I had to learn all the inner workings of the ketogenic diet. How exactly everything broke down step by step in the body. Most of you will not have the interest to know any of this nor would you need to. But because of my health situation it caused me to really dig deep into this subject. I studied the ketogenic diet for one full year before implementing it into my life.

I have to go for blood work every 6 months for my liver. After 6 months my liver function panel started slowly getting better. After one year even better. The doctor said I don`t know what you`re doing but whatever it is keep on doing it. After 2 years all of my blood work for my liver was totally normal. Today after almost 3 years on the ketogenic diet all of my liver function is totally normal. All of my blood work is totally normal. My doctor says he knows I still have the disease because of the results of my liver biopsy. But he also says that if he just goes by the blood work that I no longer have the disease!

Also there are a few more things that a ketogenic diet has done for me

1-After my initial weight loss of 163# I had lost a lot of muscle and bone and was not healthy. Once I was fat-adapted and using fat as my energy source I regained that lost muscle and bone density. Today I weigh 195# and have maintained this weight for over 2 years now.

2- After having been diagnosed type 2 diabetic in April of 2005 and told I would probably need insulin in the near future. Today my fasting blood sugar is 72-83 My A1C is 4.4 which is an average blood sugar of 79. My fasting insulin is 2.2. This is all with no diabetes meds only diet.

3-My cholesterol and triglycerides before ketogenic Trigs-200 HDL-29 LDL-100 My cholesterol and trigs today Trigs-38 HDL-105 LDL-64

4- My pain that I have from all my surgeries is much more manageable with a ketogenic diet. I am still drug free.

5-I still need a cane or walker to walk but I no longer need a handicap motorized cart in stores.

I am still confined pretty much to my lazy boy chair and still cannot lay in a bed to sleep. But I still ride my stationary bike every morning. I am 55 years old but I can honestly say I feel like I was 30 years old. I am full of energy and have very clear thinking. I now feel good about my life for the first time in a long time. I feel that I have many many more years ahead of me! And I truly believe that this is only possible because of the ketogenic diet!

Thank you to everyone that took the time to read

KRAFT Interview now has pro SPANISH Subtitles! #hyperinsulinemia #cardiovascular #diabetes

A huge thanks goes out to Dr. Pedro Aceves - he has just translated all of Dr. Kraft's discussion into perfect Spanish. Myself and Dr. Jeff Gerber met Dr. Aceves at the Low Carb Vail. He described the diabetic disaster that has befallen Mexico, something that upsets him greatly. He immediately offered to translate this key interview into proper Spanish to benefit the multitude. We are very grateful indeed for his painstaking work.

Note that my intro is still in a more generic auto-translate version. The key thing is that all of Kraft's words are professionally rendered ! Choose subtitles from 'settings' button on bottom right of screen...!

#HDL a Problem? More Misleading BS from the Pharma Anti-Science Machine - Utter Rot.

Sobriety-inspired note: I penned this in a fit of pique last night, after a family celebration which involved vast quantities of great wine. Many enjoyed the bilious burst, but some called histrionics - fair point indeed.  I am leaving the post in place however - 'for posterior', if nothing else. Also, there's an element of 'in vino veritas' about it that many seemed to enjoy...thanks  :-)

Oh God here we go again. Many mails to me this evening on the latest round of inflated science - this time about our old favourite HDL. So apparently the message is "ooooh HDL can be BAD too - watch out - scaaary stuff !!". I sighed with resignation before even reading it. I knew what was coming. More hype. But what is the real story behind this latest scaremongering? (here is one example of the media splurge:  http://www.bbc.co.uk/news/health-35775318 )

So are avocado's gonna kill you now? Well look at this prize picture from no less than the BBC:

Utter shite - again. The story as related to us is of course misleading. There is a concerted effort to obfuscate the beneficial indication of high HDL. Well of course, why wouldn't there be? High HDL only benefits low-carb supporters - not tolerable that. Holegrains and industrial oils have to be good, right? Also, billion-dollar attempts to chemically force higher HDL have resulted in abject failure. Genuine benefits can only be achieved via real food & nutrition that reduces Insulin Resistance - most irksome for the Chemical Brothers. Also, high HDL exposes the LDL hypothesis weakness - high LDL not really a problem with high HDL - oops. So there are many reasons to take shots at the benefits of high HDL. It threatens tens of billions of dollars in profits. Food. Pharma. Oodles of profit centers. It's universally infuriating to the people who really pay the piper -the funders of our 'thought leaders'. There is some merit in the paper of course - if only it was used solely for scientific purposes. But this doesn't happen - inevitably these things get pumped for all the wrong reasons. Fuel for the fire of misinformation.

So what IS the latest fabricated fuss then? Well, a rare genetic mutation leaves 1 in 1700 people with dysfunctional HDL. Their lipoproteins don't work like they should. That's it. That's just about it. But wait a second - did I say 1 in 1700? That's around 0.05% of the population??? Yes, I did. So WTF is all the media attention about? Why all the gushing and pictures of now-toxic avocados? Well I think I explained that in paragraph 2 above. What an unmitigated farce. It is not even worth my time to explain it further. They must think we are all idiots to even read this trash. In many cases, they may be correct.

Below are a couple of links that speak to HDL importance. They are rather more useful than rare-as-hens-teeth genetic peculiarities. There are instances where high HDL is not necessarily good. Of course there are. Excessive alcohol intake is one scenario. Efflux capacity and takeup are important - not all HDL is created equal. But this 1/1700 genetic variant has been used nefariously indeed:

http://www.tinyurl.com/htrecdt-

http://www.tinyurl.com/q89m95b

Black Swan Collection - for LDLc and LDLp/ApoB - enjoy

A few people have asked me to catalogue the small selection of 'Black Swans' that I've collected around the old 'cholesterol'. Here you go. LDLc first:

http://www.tinyurl.com/huzn38a

http://www.thefatemperor.com/blog/2014/11/12/ldl-its-not-the-bad-cholesterol-thats-simplistic-foolery

http://www.thefatemperor.com/blog/2015/4/25/lchf-motherlode-paper-ldlp-my-butt-insulin-and-c-peptide-rules-atheroscleosis 

http://www.thefatemperor.com/blog/2015/4/3/cholesterol-ldl-cac-progression-illuminates-fundamental-truths-lchf2015

http://www.thefatemperor.com/blog/2014/11/19/carb-driven-small-dense-ldl-means-lower-ldlc-is-higher-risk-excellent-paper

http://static1.squarespace.com/static/52faa95ee4b0b0a74811f732/t/546d1101e4b0be79099566bc/1416433921832/Excellent+but+based+on+post-MI+patients+ApoB+trumps+LDL-C+2137.full.pdf

And a few for LDLp/Apob - pity there are so few studies that bothered to highlight the absurdities, oh well:

http://www.thefatemperor.com/blog/2015/5/4/cholesterol-versus-insulin-resistance-found-an-ir-vs-apob-direct-compare

http://www.tinyurl.com/hvznbqf

http://www.thefatemperor.com/blog/2016/3/3/more-ldlp-apob-fun-just-another-associational-surrogate-im-afraid-insulin

http://tinyurl.com/z7mw74j

http://www.thefatemperor.com/blog/2015/5/5/hilarious-apob-now-being-used-as-predictor-of-insulin-resistance-cholesterol-lchf

http://www.tinyurl.com/q89m95b

Ooops - nearly forget our little El Pee Little Ay (Lp(a)):

http://www.thefatemperor.com/blog/2014/11/20/asked-about-lpa-more-later-but-heres-a-taster

http://www.thefatemperor.com/blog/2015/4/22/cholesterol-health-scare-emperor-has-high-lpa-el-pee-little-a

http://www.tinyurl.com/j4mvq7w

Enjoy. :-)

 

 

 

 

#cardiovascular Disease Prediction. Screw CIMT. CAC Rules the Roost.

Great paper here from the inimitable Dr. Jeff Gerber. I always found CIMT to be a weak predictor. Here's a good summary of why. The coronary CT Scan and CAC Calcium Score blows it away. Like an Autumn leaf. Or a feather maybe. Something light and trite in any case...! Click on link below for scintillating study (Conclusion from same in panel underneath):

CIMT No Bueno Peeps

Here's another super paper from Rakesh Patel (a cardiovascular genius-type - follow him on twitter: @drrcpatel ) - http://theheartattackandstrokepreventioncenter.com/wp-content/uploads/2011/08/CIMT-Article-03.20.13-Doneen-Bale-1.pdf

Now look at advancing CAC Score in comparison - almost like stepping into a time machine, and seeing the future. If your CAC is rising, the Reaper is very close:

CIMT my arse. Why is it so shite for prediction? Here's a clue: http://aje.oxfordjournals.org/content/95/1/26.short  And no it wasn't the Maasai walking around all day that made their arteries thick but solid as a rock. It was their lack of hyperinsulinemia. CIMT is a noisy distraction, because it doesn't speak to root cause of hard end points. It speaks to the body's natural processes. Seems it's about as useful as ApoB, especially for a LCHF person :-)

Why is ApoB such a Sneaky Surrogate ? And where is ApoA1?

On a bit of an ApoB roll here this eve. It is such an annoying associational variable, that scares the poor low carbers who come in high. We'll put aside the actual data, which suggests that ApoB is a poor indicator for LCHF low-IR people. Based on logic, why might the high number be irrelevant for low-IR LCHF types? Think about it for a moment:

1. For NON Insulin Resistant (NON Metabolic Syndrome) people, there is good concordance between LDLc and LDLp. High LDLc generally goes with high LDLp. We now know that LDLc is bullshit biometric, with essentially no meaning outside of the hyperinsulinemic hordes. So we can forget LDLp for these non-IR people also, along with the risible LDLc.

2. For Insulin Resistant Met Syn peeps, there is discordance between LDLc and LDLp. Thus you can have low LDLc with high LDLp. The high LDLp now becomes an excellent reflector of Insulin Resistance itself. So you gotta watch the LDLp in this scenario - it now associates strongly with heart events. (the farcical LDLc is of course worse than useless here). But hold on a minute - in these IR people the LDLp is acting as a surrogate for IR - so why the hell would you use this devious metric for Low-IR LCHF peeps?

Whether 1. or 2. above, LDLp is the associational variable from hell. What a goddamn mess... :-)

p.s.We haven't even mentioned ApoA1 here. If anything, ApoB/ApoA1 is the only metric that should be looked at - it is far more powerful than ApoB alone. Of course healthy LCHF peeps with high ApoB will generally have a good ApoB/ApoA1 ratio. Dum de dum...what sleight of hand this particle-count trickery really is...!

From the great AMORIS Study, with nearly 180,000 people tracked across many countries: http://www.ncbi.nlm.nih.gov/pubmed/11755609 .  Only a devious idiot would use ApoB rather than ApoB/ApoA1. It's a joke:


Follow the money for repeat Heart Attacks: No, not #cholesterol - rather #Insulin :-)

Isn't that an interesting question - especially for people who have proven Coronary Artery DIsease?  If you've been reading recent posts, you may take a guess at this one. Ok, I'll put you out of hanging in suspenders there, and show you the results of this nice little study; again small sampling mathematical theory applies - the stats take care of the moderate numbers, so don't be whining unless you think you know better:  The Study:

"Insulin Resistance and Fasting Hyperinsulinemia Are Risk Factors for New Cardiovascular Events in Patients With Prior Coronary Artery Disease and Normal Glucose Tolerance" Circ J 2004; 68: 47 –52

The Results - let's see how these coronary diseased people fared, when followed over three years - versus the careful measurements taken up front. Was it the statin treatment? Eh, no - more event people were on the statins. Was it the LDL? Eh, no again - they were lower if anything. Was it the HDL? sorta - not shown here, but it made the grade in the univariate analysis as can be guessed from the table. So what hammered every other variable into the ground, in giving you that second event???

Right - it was the Insulin Resistance - quelle surprise.

We don't have their LDL-P, but I'm guessing it would have shown up as significant in the 'event people'....what with their low HDL and all. But still just an associational surrogate for the real thing. Slightly less farcical than LDLc maybe...  ;-)

It's the #Insulin Stupid - Again ! #Diabetes #HDL

Oh here we go again; I'll never tire of reminding people that Insulin sits at the center of Heart Disease risk, and most other modern afflictions also.

Here are a couple of great papers - the first deals with C-Peptide levels and the Mortality Reality (for 'C-Peptide' read 'Insulin'). The second also deals with C-Peptide, and crosses it with our old friend HDLc; one reason why higher HDLc is good for you, is it tracks with LOW C-Peptide). Of course if you have lower HDLc, but also LOW C-Peptide, that can be cool too - work it out peeps:

http://dvr.sagepub.com/content/early/2015/02/10/1479164114564900.full.pdf+html

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283961/pdf/pone.0112281.pdf

The takeaway? Insulin levels as denoted by C-Peptide rule the roost of modern disease - and until these are tackled and lowered, we're beating around the bush with silly cholesterol surrogates. LCHF anyone? Mmmnn yeah.

Excerpt 1:  From the first paper, Green line shows the horrendous mortality implications of having higher C-Peptide (even while still retaining ok glycemic control for this 'Group 2'):

Excerpt 2: And from the second paper here's one reason why HDLc being lower is such a predictor of death - it goes hand-in-hand with HIGH C-Peptide levels:

What's wrong with researchers in the Heart Disease arena - do they need their noses rubbed in the Insulin mess like puppies? Root Cause analysis house-training - that's what's needed.

I give up - not:-)